Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study
Abstract Objective Calcitonin receptor-like receptor (CRLR) regulates vasoconstriction and dilatation; the expression increases during hypoxia via activation of hypoxia response element (HRE) in CRLR gene promoter region. Variant in HRE, as well short tandem repeat (STR) variants near HRE in CRLR al...
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doaj-4e85038e7bcc49b4a478a3c89b65704b2021-01-10T12:51:15ZengBMCBMC Research Notes1756-05002021-01-011411510.1186/s13104-020-05437-zShort tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary studyHerlambang0Amelia Dwi Fitri1Ahmad Syauqy2Yuwono3Anggelia Puspasari4Rina Nofri Enis5Ahmad Faried6Department of Obstetrics and Gynaecology, Division of Fetomaternal, Faculty of Medicine and Health Sciences, University of Jambi (FKIK UNJA)-Raden Mattaher General Hospital (RSRM)FKIK UNJA-RSRMDepartment of Medical Biology and Biochemistry FKIK, UNJA-RSRMDepartment of Microbiology, Faculty of Medicine, University of SriwijayaDepartment of Medical Biology and Biochemistry FKIK, UNJA-RSRMDepartment of Anatomy, FKIK UNJA-RSRMOncology and Stem Cell Working Group, Faculty of Medicine, Universitas Padjadjaran-Dr, Hasan Sadikin HospitalAbstract Objective Calcitonin receptor-like receptor (CRLR) regulates vasoconstriction and dilatation; the expression increases during hypoxia via activation of hypoxia response element (HRE) in CRLR gene promoter region. Variant in HRE, as well short tandem repeat (STR) variants near HRE in CRLR alters the gene expression. This study focused on a case–control study to investigate the expression of genetic typing CLRL promoter variant in pregnant women with severe preeclampsia and normal pregnancies, we also tried to describe interesting findings of the genetic expression in anemic patients in the severe preeclampsia group. Our aimed to observe the correlation of CRLR gene promoter variant and anemia in severe preeclampsia. Results There was no nucleotide variant in HRE; CACA box prior to HRE varied in length (15–24); CACA box with length > 20 was used as cut off point. Hb was lower in CACA box length ≥ 21 (10.33 ± 1.57) vs. < 21 (11.01 ± 1.67; p = 0.391). CACA box polymorphism and anemia were correlated in severe preeclampsia (p = 0.005) OR 0.038 (CI 0.003–0.544); not in normal (p = 0.069).https://doi.org/10.1186/s13104-020-05437-zPreeclampsiaCRLRCA repeatHRECACA box polymorphGene promoter |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Herlambang Amelia Dwi Fitri Ahmad Syauqy Yuwono Anggelia Puspasari Rina Nofri Enis Ahmad Faried |
spellingShingle |
Herlambang Amelia Dwi Fitri Ahmad Syauqy Yuwono Anggelia Puspasari Rina Nofri Enis Ahmad Faried Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study BMC Research Notes Preeclampsia CRLR CA repeat HRE CACA box polymorph Gene promoter |
author_facet |
Herlambang Amelia Dwi Fitri Ahmad Syauqy Yuwono Anggelia Puspasari Rina Nofri Enis Ahmad Faried |
author_sort |
Herlambang |
title |
Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study |
title_short |
Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study |
title_full |
Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study |
title_fullStr |
Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study |
title_full_unstemmed |
Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study |
title_sort |
short tandem repeat near hypoxia response element (hre) instead of hre genetic variants in promoter calcitonin receptor-like receptor (crlr) gene as risk factor in severe preeclampsia: a preliminary study |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2021-01-01 |
description |
Abstract Objective Calcitonin receptor-like receptor (CRLR) regulates vasoconstriction and dilatation; the expression increases during hypoxia via activation of hypoxia response element (HRE) in CRLR gene promoter region. Variant in HRE, as well short tandem repeat (STR) variants near HRE in CRLR alters the gene expression. This study focused on a case–control study to investigate the expression of genetic typing CLRL promoter variant in pregnant women with severe preeclampsia and normal pregnancies, we also tried to describe interesting findings of the genetic expression in anemic patients in the severe preeclampsia group. Our aimed to observe the correlation of CRLR gene promoter variant and anemia in severe preeclampsia. Results There was no nucleotide variant in HRE; CACA box prior to HRE varied in length (15–24); CACA box with length > 20 was used as cut off point. Hb was lower in CACA box length ≥ 21 (10.33 ± 1.57) vs. < 21 (11.01 ± 1.67; p = 0.391). CACA box polymorphism and anemia were correlated in severe preeclampsia (p = 0.005) OR 0.038 (CI 0.003–0.544); not in normal (p = 0.069). |
topic |
Preeclampsia CRLR CA repeat HRE CACA box polymorph Gene promoter |
url |
https://doi.org/10.1186/s13104-020-05437-z |
work_keys_str_mv |
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