Hemozoin produced by mammals confers heme tolerance

Hemozoin produced by mammals confers heme tolerance

Free heme is cytotoxic as exemplified by hemolytic diseases and genetic deficiencies in heme recycling and detoxifying pathways. Thus, intracellular accumulation of heme has not been observed in mammalian cells to date. Here we show that mice deficient for the heme transporter SLC48A1 (also known as...

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Bibliographic Details
Main Authors: Rini H Pek, Xiaojing Yuan, Nicole Rietzschel, Jianbing Zhang, Laurie Jackson, Eiji Nishibori, Ana Ribeiro, William Simmons, Jaya Jagadeesh, Hiroshi Sugimoto, Md Zahidul Alam, Lisa Garrett, Malay Haldar, Martina Ralle, John D Phillips, David M Bodine, Iqbal Hamza
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
heme
anemia
iron
hemozoin
macrophages
lysosome
Online Access:https://elifesciences.org/articles/49503

Internet

https://elifesciences.org/articles/49503

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