Bioreactor Suspension Culture: Differentiation and Production of Cardiomyocyte Spheroids From Human Induced Pluripotent Stem Cells

Bioreactor Suspension Culture: Differentiation and Production of Cardiomyocyte Spheroids From Human Induced Pluripotent Stem Cells

Human induced-pluripotent stem cells (hiPSCs) can be efficiently differentiated into cardiomyocytes (hiPSC-CMs) via the GiWi method, which uses small-molecule inhibitors of glycogen synthase kinase (GSK) and tankyrase to first activate and then suppress Wnt signaling. However, this method is typical...

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Bibliographic Details
Main Authors: Asher Kahn-Krell, Danielle Pretorius, Jianfa Ou, Vladimir G. Fast, Silvio Litovsky, Joel Berry, Xiaoguang (Margaret) Liu, Jianyi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
pluripotent stem cell
cardiomyocyte
suspension culture
maturation
robust scale-up
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.674260/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.674260/full

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