The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling

The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling

Marginal zone B (MZB) cells shuttle between the marginal zone and lymphoid follicle to capture and present peripheral blood antigens. Here the authors show that shear force, such as blood flow from the sinus around the follicle, is a directional cue that induces MZB migration on ICAM-1, and that S1P...

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Bibliographic Details
Main Authors: Kerry Tedford, Michael Steiner, Stanislav Koshutin, Karin Richter, Laura Tech, Yannik Eggers, Inga Jansing, Kerstin Schilling, Anja Erika Hauser, Mark Korthals, Klaus-Dieter Fischer
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02482-4

Internet

https://doi.org/10.1038/s41467-017-02482-4

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