Sensitivity to sequencing depth in single-cell cancer genomics

Sensitivity to sequencing depth in single-cell cancer genomics

Abstract Background Querying cancer genomes at single-cell resolution is expected to provide a powerful framework to understand in detail the dynamics of cancer evolution. However, given the high costs currently associated with single-cell sequencing, together with the inevitable technical noise ari...

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Bibliographic Details
Main Authors: João M. Alves, David Posada
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Genome Medicine
Subjects:
Single-cell sequencing
Intratumor genetic heterogeneity
Variant calling
Clonal inference
Tumor phylogenies
Online Access:http://link.springer.com/article/10.1186/s13073-018-0537-2

Internet

http://link.springer.com/article/10.1186/s13073-018-0537-2

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