Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock

Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock

Sepsis is a life-threating multi-organ disease induced by host innate immunity to pathogen-derived endotoxins including lipopolysaccharide (LPS). Direct sensing of LPS by caspase-11 activates inflammasomes and causes lethal sepsis in mice. Inhibition of caspase-11 inflammasomes is important for the...

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Bibliographic Details
Main Authors: Naoya Sakaguchi, Miwa Sasai, Hironori Bando, Youngae Lee, Ariel Pradipta, Ji Su Ma, Masahiro Yamamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
GBP2
Gate-16
caspase-11
non-canonical inflammasome
sepsis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.561948/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.561948/full

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