Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice

Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice

The disruption of gut microbes is associated with diabetic cardiomyopathy, but the mechanism by which gut microbes affect cardiac damage remains unclear. We explored gut microbes and branched-chain amino acid (BCAA) metabolite catabolism in diabetic cardiomyopathy mice and investigated the cardiopro...

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Bibliographic Details
Main Authors: Yang Yang, Ming Zhao, Xi He, Qing Wu, Dong-Ling Li, Wei-Jin Zang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
diabetic cardiomyopathy
gut microbiota
branched-chain amino acids
pyridostigmine
mitochondrial dysfunction
vagal activity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.647481/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.647481/full

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