Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.

Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.

Specificity within protein kinase signaling cascades is determined by direct and indirect interactions between kinases and their substrates. While the impact of localization and recruitment on kinase-substrate targeting can be readily assessed, evaluating the relative importance of direct phosphoryl...

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Bibliographic Details
Main Authors: Chad J Miller, Hua Jane Lou, Craig Simpson, Bert van de Kooij, Byung Hak Ha, Oriana S Fisher, Natasha L Pirman, Titus J Boggon, Jesse Rinehart, Michael B Yaffe, Rune Linding, Benjamin E Turk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2006540

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https://doi.org/10.1371/journal.pbio.2006540

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