Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation

Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation

Periplaneta americana, a magic medicinal insect being present for over 300 million years, exhibits desirable therapeutic outcome for gastrointestinal ulcer treatment. Nowadays, P. americana ethanol extract (PAE) has been shown to ameliorate ulcerative colitis (UC) by either single-use or in combinat...

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Bibliographic Details
Main Authors: Xuewei Ma, Yichen Hu, Xin Li, Xiaoting Zheng, Yitao Wang, Jinming Zhang, Chaomei Fu, Funeng Geng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
ulcerative colitis
Periplaneta americana
16S rRNA
gut microbiota
intestinal immunity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00944/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00944/full

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