Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy

Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy

Abstract Background Ligands of the receptor for advanced glycation end products (RAGE) are key signalling molecules in the innate immune system but their role in tuberculosis-diabetes comorbidity (TB-DM) has not been investigated. Methods We examined the systemic levels of soluble RAGE (sRAGE), adva...

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Bibliographic Details
Main Authors: Nathella Pavan Kumar, Kadar Moideen, Arul Nancy, Vijay Viswanathan, Basavaradhya S. Shruthi, Shanmugam Sivakumar, Syed Hissar, Hardy Kornfeld, Subash Babu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Infectious Diseases
Subjects:
Mycobacterium tuberculosis
Diabetes mellitus
RAGE ligands
Online Access:https://doi.org/10.1186/s12879-019-4648-1

Internet

https://doi.org/10.1186/s12879-019-4648-1

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