Aberrant Promoter Methylation of Sparc in Ovarian Cancer

Epigenetic silencing of tumor suppressor genes is a new focus of investigation in the generation and proliferation of carcinomas. Secreted protein acidic and rich in cysteine (SPARC) is reportedly detrimental to the growth of ovarian cancer cells and has been shown to be epigenetically silenced in...

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Bibliographic Details
Main Authors: Matthew J. Socha, Neveen Said, Yanshan Dai, Joseph Kwong, Preetha Ramalingam, Vuong Trieu, Neil Desai, Samuel C. Mok, Kouros Motamed
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609800250