One-dimensional diffusion of TrpR along DNA enhances its affinity for the operator by chemical ratchet mechanism

Abstract Several DNA-binding proteins show the affinities for their specific DNA sites that positively depend on the length of DNA harboring the sites, i. e. antenna effect. DNA looping can cause the effect for proteins with two or more DNA binding sites, i. e. the looping mechanism. One-dimensional...

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Bibliographic Details
Main Authors: Takashi Kinebuchi, Nobuo Shimamoto
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83156-6