Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39

Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39

Pyrimidine nucleotides play an important role in the biosynthesis of activated nucleotide sugars (NDP-sugars). NDP-sugars are the precursors of structural polysaccharides in bacteria, including capsule, which is a major virulence factor of the human pathogen S. pneumoniae. In this work, we identifie...

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Bibliographic Details
Main Authors: Sandra M. Carvalho, Tomas G. Kloosterman, Irfan Manzoor, José Caldas, Susana Vinga, Jan Martinussen, Lígia M. Saraiva, Oscar P. Kuipers, Ana R. Neves
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
Streptococcus pneumoniae
spontaneous mutations
uracil metabolism
capsule biosynthesis
gene expression
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00321/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00321/full

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