HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function[S]

HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function[S]

HDL functions are impaired by myeloperoxidase (MPO), which selectively targets and oxidizes human apoA1. We previously found that the 4WF isoform of human apoA1, in which the four tryptophan residues are substituted with phenylalanine, is resistant to MPO-mediated loss of function. The purpose of th...

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Bibliographic Details
Main Authors: Stela Z. Berisha, Greg Brubaker, Takhar Kasumov, Kimberly T. Hung, Patricia M. DiBello, Ying Huang, Ling Li, Belinda Willard, Katherine A. Pollard, Laura E. Nagy, Stanley L. Hazen, Jonathan D. Smith
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein A1
dysfunctional high density lipoprotein
reverse cholesterol transport
myeloperoxidase
cholesterol efflux
ATP binding cassette transporter A1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355930

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http://www.sciencedirect.com/science/article/pii/S0022227520355930

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