Screening for hotspot mutations in PI3K, JAK2, FLT3 and NPM1 in patients with myelodysplastic syndromes

Screening for hotspot mutations in PI3K, JAK2, FLT3 and NPM1 in patients with myelodysplastic syndromes

INTRODUCTION: Myelodysplastic syndromes encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, refractory cytopenia and a tendency to progress toward acute myeloid leukemia. The accumulation of genetic alterations is closely associated...

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Bibliographic Details
Main Authors: João Agostinho Machado-Neto, Fabiola Traina, Mariana Lazarini, Paula de Melo Campos, Katia Borgia Barbosa Pagnano, Irene Lorand-Metze, Fernando Ferreira Costa, Sara T Olalla Saad
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2011-01-01
Series:Clinics
Subjects:
Hematopoietic Disorder
Acute Leukemia
Myelodysplasia
Mutations
Bone Marrow
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000500014

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000500014

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