X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB

Guan and Hariharan report two crystal structures of melibiose transporter MelB in complex with substrate analogs, nitrophenyl-galactoside, and dodecyl-melibioside. Both structures revealed similar specific site for sugar recognition and resolved the cation-binding pocket, advancing the understanding...

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Bibliographic Details
Main Authors: Lan Guan, Parameswaran Hariharan
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02462-x