Application of calibrated forceps for assessing mechanical nociception with high time resolution in mice.

In order to investigate the basic physiological mechanisms of pain and the anti-nociceptive effects of analgesics, development of pain assays in mice is critical due to the advances of genetic manipulation techniques. The von Frey hairs/Semmes-Weinstein monofilaments test (von Frey test) has long be...

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Bibliographic Details
Main Authors: Hideki Kashiwadani, Yuichi Kanmura, Tomoyuki Kuwaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5315314?pdf=render