A Protocol for Dual Calcium-Voltage Optical Mapping in Murine Sinoatrial Preparation With Optogenetic Pacing

A Protocol for Dual Calcium-Voltage Optical Mapping in Murine Sinoatrial Preparation With Optogenetic Pacing

Among the animal models for studying the molecular basis of atrial and sinoatrial node (SAN) biology and disease, the mouse is a widely used species due to its feasibility for genetic modifications in genes encoding ion channels or calcium handling and signaling proteins in the heart. It is therefor...

Full description

Bibliographic Details
Main Authors: Ruirui Dong, Razik Mu-u-min, Alastair J. M. Reith, Christopher O’Shea, Shicheng He, Kaizhong Duan, Kun Kou, Alexander Grassam-Rowe, Xiaoqiu Tan, Davor Pavlovic, Xianhong Ou, Ming Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
sinoatrial preparation
optogenetic pacing
optical mapping
murine heart
Ca2+ transient
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00954/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00954/full

Similar Items