NT-4/5 Exacerbates Free Radical-Induced Neuronal Necrosis in Vitro and in Vivo

NT-4/5 Exacerbates Free Radical-Induced Neuronal Necrosis in Vitro and in Vivo

Neurotrophins render neurons highly vulnerable to certain injuries. We examined the possibility that NT-4/5 would enhance free radical neurotoxicity in vivo as well as in vitro. Striatal neurons exposed to 10 μM Fe2+ or 1 mM l-buthionine-[S, R]-sulfoximine (BSO) underwent mild degeneration within 24...

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Bibliographic Details
Main Authors: Seok J. Won, Eun C. Park, Bo R. Ryu, Hyuk W. Ko, Seonghyang Sohn, Hyuk J. Kwon, Byoung J. Gwag
Format: Article
Language:English
Published: Elsevier 2000-08-01
Series:Neurobiology of Disease
Subjects:
NT-4/5
oxidative stress
free radical
necrosis
striatal cell culture
striatum
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100902845

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http://www.sciencedirect.com/science/article/pii/S0969996100902845

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