Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study

Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study

Background: Brain lipid metabolism appears critical for cognitive aging, but whether alterations in the lipidome relate to cognitive decline remains unclear at the system level. Methods: We studied participants from the Three-City study, a multicentric cohort of older persons, free of dementia at ti...

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Bibliographic Details
Main Authors: Sophie Lefèvre-Arbogast, Boris P Hejblum, Catherine Helmer, Christian Klose, Claudine Manach, Dorrain Y Low, Mireia Urpi-Sarda, Cristina Andres-Lacueva, Raúl González-Domínguez, Ludwig Aigner, Barbara Altendorfer, Paul J Lucassen, Silvie R Ruigrok, Chiara De Lucia, Andrea Du Preez, Cécile Proust-Lima, Sandrine Thuret, Aniko Korosi, Cécilia Samieri
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:EBioMedicine
Subjects:
Cognitive dysfunction
Dementia
Membrane lipids
Metabolomics
Lipidomics
Serum biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000098

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http://www.sciencedirect.com/science/article/pii/S2352396421000098

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