Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways

Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways

Background/Aims: Adipocyte-derived exosomes (ADEs) stimulate the activation of macrophages and contribute to the development of insulin resistance. Sonic Hedgehog (Shh) is an exosome-carrying protein and stimulates macrophages to secrete inflammatory cytokines. However, the impact of ADEs carrying S...

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Bibliographic Details
Main Authors: Ming Song, Lu Han, Fang-fang Chen, Di Wang, Feng Wang, Lei Zhang, Zhi-hao Wang, Ming Zhong, Meng-xiong Tang, Wei Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Exosome
Insulin resistance
Macrophage polarization
Sonic hedgehog
Online Access:https://www.karger.com/Article/FullText/492252

Internet

https://www.karger.com/Article/FullText/492252

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