Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator

Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator

Pyruvate kinase activity is controlled by a tightly woven regulatory network. The oncofetal isoform of pyruvate kinase (PKM2) is a master regulator of cancer metabolism. PKM2 engages in parallel, feed-forward, positive and negative feedback control contributing to cancer progression. Besides its met...

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Bibliographic Details
Main Author: Fabian V Filipp
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Carcinogenesis
Subjects:
Cancer metabolism
catenin
control
epidermal growth factor receptor
feed-forward
feedback
fructose-1
6-bisphosphate
6-bisphosphatase
glutamic-oxalacetic transaminase
glutaminase
hypoxia-inducible factor 1-alpha
isoform
metabolomics
MYC
NMR
omics
pyruvate dehydrogenase
pyruvate dehydrogenase kinase
PKM1
PKM2
pyruvate kinase M2
pyruvate kinase
succinylaminoimidazolecarboxamide ribose-5-phosphate
seven in absentia homolog 2
serine
serine/arginine-rich splicing factor 3
signal transducer and activator of transcription 3
systems biology
Warburg
Online Access:http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=14;epage=14;aulast=Filipp

Internet

http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=14;epage=14;aulast=Filipp

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