Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

Abstract Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is highly complex with constant features, such as mental retardation, dysmorphic traits and hypotonia, and variable features inclu...

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Bibliographic Details
Main Authors: Antonella Izzo, Nunzia Mollo, Maria Nitti, Simona Paladino, Gaetano Calì, Rita Genesio, Ferdinando Bonfiglio, Rita Cicatiello, Maria Barbato, Viviana Sarnataro, Anna Conti, Lucio Nitsch
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Molecular Medicine
Subjects:
Down syndrome/trisomy of chromosome 21
Mitochondrial dysfunction
Mitochondrial dynamics
Chromosome 21 genes
Down syndrome therapy
Online Access:http://link.springer.com/article/10.1186/s10020-018-0004-y

Internet

http://link.springer.com/article/10.1186/s10020-018-0004-y

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