Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor

Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor

Progression to AD is preceded by elevated levels of 2,4-dihydroxybutanoic acid (2,4-DHB), implicating hypoxia in early pathogenesis. Since hypoxia may play a role in multiple CNS disorders, we investigated serum metabolite profiles across three disorders, AD, Normal Pressure Hydrocephalus (NPH) and...

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Bibliographic Details
Main Authors: Matej Orešič, Gabriella Anderson, Ismo Mattila, Manoucher Manoucheri, Hilkka Soininen, Tuulia Hyötyläinen, Cherlynn Basignani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer's disease
brain tumor
hypoxia
metabolomics
normal pressure hydrocephalus
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00747/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00747/full

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