A Regulator Based “Semi-Targeted” Approach to Activate Silent Biosynthetic Gene Clusters

A Regulator Based “Semi-Targeted” Approach to Activate Silent Biosynthetic Gene Clusters

By culturing microorganisms under standard laboratory conditions, most biosynthetic gene clusters (BGCs) are not expressed, and thus, the products are not produced. To explore this biosynthetic potential, we developed a novel “semi-targeted” approach focusing on activating “silent” BGCs by concurren...

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Bibliographic Details
Main Authors: Erik Mingyar, Lucas Mühling, Andreas Kulik, Anika Winkler, Daniel Wibberg, Jörn Kalinowski, Kai Blin, Tilmann Weber, Wolfgang Wohlleben, Evi Stegmann
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
regulation
streptomyces
secondary metabolites
silent biosynthetic gene cluster
Online Access:https://www.mdpi.com/1422-0067/22/14/7567

Internet

https://www.mdpi.com/1422-0067/22/14/7567

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