Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca2+/CaMKII/CREB Signaling Pathway

Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca2+/CaMKII/CREB Signaling Pathway

Paeoniflorin (PF) is an active ingredient of Paeoniae Radix which possesses the neuroprotective effect. However, so far, the neuroprotective mechanism of PF has still not been fully uncovered. The Ca2+/Ca2+/calmodulin-dependent protein kinase II (CaMKII)/cAMP response element-binding (CREB) signalin...

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Bibliographic Details
Main Authors: Yuqin Zhang, Lifei Qiao, Wen Xu, Xiaoying Wang, Huang Li, Wei Xu, Kedan Chu, Yu Lin
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Molecules
Subjects:
ischemic stroke
paeoniflorin
middle cerebral artery occlusion
CREB
CaMKII
Online Access:http://www.mdpi.com/1420-3049/22/3/359

Internet

http://www.mdpi.com/1420-3049/22/3/359

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