Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site

Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site

The serotonin 1A receptor (5-HT1A), a critical regulator of the brain serotonergic tone, is implicated in major depressive disorder (MDD) where it is often found to be dys-regulated. However, the extent to which stress and antidepressant treatment impact 5-HT1A expression in adults remains unclear....

Full description

Bibliographic Details
Main Authors: Brice Le François, Jeremy Soo, Anne M. Millar, Mireille Daigle, Anne-Marie Le Guisquet, Samuel Leman, Frédéric Minier, Catherine Belzung, Paul R. Albert
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Serotonin
UCMS
Raphe
DNA methylation
Sp4
Antidepressant
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611530005X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611530005X

Similar Items