Alternate subunit assembly diversifies the function of a bacterial toxin
Salmonella Typhi produces the typhoid toxin. Here, Fowler et al. show that S. Typhi produces two forms of typhoid toxin that are differentially regulated and display different trafficking properties and different effects when administered to laboratory animals.
Main Authors: | Casey C. Fowler, Gabrielle Stack, Xuyao Jiao, Maria Lara-Tejero, Jorge E. Galán |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11592-0 |
Similar Items
-
Therapeutic Uses of Bacterial Subunit Toxins
by: Clifford Lingwood
Published: (2021-05-01) -
A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses
by: Maria Lara-Tejero
Published: (2001-01-01) -
Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen.
by: Shu-Jung Chang, et al.
Published: (2019-04-01) -
Cholera toxin B subunits assemble into pentamers--proposition of a fly-casting mechanism.
by: Jihad Zrimi, et al.
Published: (2010-01-01) -
Assembly and functionality of the ribosome with tethered subunits
by: Nikolay A. Aleksashin, et al.
Published: (2019-02-01)