Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line

Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line

Abstract Background There is compelling evidence associating senescent cells with the malignant progression of tumours. Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attracted much attention. Since the pro-inflammatory cytokines IL-6 and IL-...

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Bibliographic Details
Main Authors: Paola Ortiz-Montero, Arturo Londoño-Vallejo, Jean-Paul Vernot
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Cell Communication and Signaling
Subjects:
Senescence
IL6
IL8
Stemness
Breast cancer
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12964-017-0172-3

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http://link.springer.com/article/10.1186/s12964-017-0172-3

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