Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice

Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice

Transgenic mice overexpressing human tau with the P301L mutation develop neurofibrillary tangles, extensive gliosis, adult-onset motor abnormalities, and neuronal loss in affected brain regions. We investigated the mechanism of neuronal cell death in this model of tauopathy. There was no evidence of...

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Bibliographic Details
Main Authors: Cindy Zehr, Jada Lewis, Eileen McGowan, Julia Crook, Wen-Lang Lin, Kate Godwin, Joshua Knight, Dennis W Dickson, Mike Hutton
Format: Article
Language:English
Published: Elsevier 2004-04-01
Series:Neurobiology of Disease
Subjects:
Cell death
Tau
Tauopathy
TUNEL
Caspase-3
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002857

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http://www.sciencedirect.com/science/article/pii/S0969996103002857

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