The Metabolic Reprogramming of Frem2 Mutant Mice Embryos in Cryptophthalmos Development

The Metabolic Reprogramming of Frem2 Mutant Mice Embryos in Cryptophthalmos Development

BackgroundCryptophthalmos is characterized by congenital ocular dysplasia with eyelid malformation. The pathogenicity of mutations in genes encoding components of the FRAS1/FREM protein complex is well established, but the underlying pathomechanisms of this disease are still unclear. In the previous...

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Bibliographic Details
Main Authors: Xiayin Zhang, Ruixin Wang, Ting Wang, Xulin Zhang, Meimei Dongye, Dongni Wang, Jinghui Wang, Wangting Li, Xiaohang Wu, Duoru Lin, Haotian Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
metabonomics
Frem2 mutation
cryptophthalmos
development of eyelids
transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.625492/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.625492/full

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