Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells

Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells

Faithful chromosome segregation, driven by the mitotic spindle, is essential for organismal survival. Neopolyploid cells from diverse species exhibit a significant increase in mitotic errors relative to their diploid progenitors, resulting in chromosome nondisjunction. In the model system Saccharomy...

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Bibliographic Details
Main Authors: Ivan Jelenić, Anna Selmecki, Liedewij Laan, Nenad Pavin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Genetics
Subjects:
polyploidy
spindle assembly
chromosome loss
chromosome segregation
cell cycle regulation
theoretical modeling
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00296/full

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