Stimulation of Wnt/ß-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype.

Stimulation of Wnt/ß-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype.

Cancer can be treated by adoptive cell transfer (ACT) of T lymphocytes. However, how to optimally raise human T cells to a differentiation state allowing the best persistence in ACT is a challenge. It is possible to differentiate mouse CD8(+) T cells towards stem cell-like memory (T(SCM)) phenotype...

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Bibliographic Details
Main Authors: Marie-Andrée Forget, Yannick Huon, Alexandre Reuben, Cécile Grange, Moïshe Liberman, Jocelyne Martin, Anne-Marie Mes-Masson, Nathalie Arbour, Réjean Lapointe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3408435?pdf=render

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http://europepmc.org/articles/PMC3408435?pdf=render

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