De novo variant of TRRAP in a patient with very early onset psychosis in the context of non-verbal learning disability and obsessive-compulsive disorder: a case report

De novo variant of TRRAP in a patient with very early onset psychosis in the context of non-verbal learning disability and obsessive-compulsive disorder: a case report

Abstract Background TRRAP encodes a multidomain protein kinase that works as a genetic cofactor to influence DNA methylation patterns, DNA damage repair, and chromatin remodeling. TRRAP protein is vital to early neural developmental processes, and variants in this gene have been associated with schi...

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Bibliographic Details
Main Authors: Chrystal F. Mavros, Catherine A. Brownstein, Roshni Thyagrajan, Casie A. Genetti, Sahil Tembulkar, Kelsey Graber, Quinn Murphy, Kristin Cabral, Grace E. VanNoy, Matthew Bainbridge, Jiahai Shi, Pankaj B. Agrawal, Alan H. Beggs, Eugene D’Angelo, Joseph Gonzalez-Heydrich
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Medical Genetics
Subjects:
Psychosis
Obsessive compulsive disorder
Childhood onset psychosis
Very early onset psychosis
Major depression with psychotic features
Online Access:http://link.springer.com/article/10.1186/s12881-018-0711-9

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http://link.springer.com/article/10.1186/s12881-018-0711-9

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