Cystamine and intrabody co-treatment confers additional benefits in a fly model of Huntington's disease

Cystamine and intrabody co-treatment confers additional benefits in a fly model of Huntington's disease

Huntington's disease (HD) is a lethal, neurodegenerative disorder caused by expansion of the polyglutamine repeat in the Huntingtin gene (HTT), leading to mutant protein misfolding, aggregation, and neuronal death. Feeding a Drosophila HD model cystamine, or expressing a transgene encoding the...

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Bibliographic Details
Main Authors: S.F. Bortvedt, J.A. McLear, A. Messer, A.J. Ahern-Rindell, W.J. Wolfgang
Format: Article
Language:English
Published: Elsevier 2010-10-01
Series:Neurobiology of Disease
Subjects:
Combinatorial therapy
Neurodegenerative disease
scFv
Polyglutamine
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611000104X

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http://www.sciencedirect.com/science/article/pii/S096999611000104X

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