Epigallocatechin-3-Gallate Attenuates the Effects of TNF-α in Vascular Endothelial Cells by Causing Ectodomain Shedding of TNF Receptor 1

Epigallocatechin-3-Gallate Attenuates the Effects of TNF-α in Vascular Endothelial Cells by Causing Ectodomain Shedding of TNF Receptor 1

Background/Aims: We investigated the mechanism underlying anti-tumor necrosis factor-α (TNF-α) effects of epigallocatechin-3-gallate (EGCG) in human aortic endothelial cells. Methods: Tumor necrosis factor receptor 1 (TNFR1) was assessed by Western blot analysis. Cytosolic Ca2+ was measured using Fl...

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Bibliographic Details
Main Authors: Won Seok Yang, Soo Young Moon, Mee Jeong Lee, Su-Kil Park
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
A disintegrin and metalloprotease 10
Calcium influx
Cyclopiazonic acid
Epigallocatechin-3-gallate
Thapsigargin
Tumor necrosis factor receptor 1
Online Access:http://www.karger.com/Article/FullText/445557

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http://www.karger.com/Article/FullText/445557

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