PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity

PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity

Abstract Background The proteasome system plays an important role in synaptic plasticity. Induction and maintenance of long term potentiation is directly dependent on selective targeting of proteins for proteasomal degradation. The 20S proteasome activator PA28αβ activates hydrolysis of small nonubi...

Full description

Bibliographic Details
Main Authors: Julia Adelöf, My Andersson, Michelle Porritt, Anne Petersen, Madeleine Zetterberg, John Wiseman, Malin Hernebring
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Neuroscience
Subjects:
PA28αβ
Learning and memory
F2 hybrid transgenic mice
Behavioral phenotyping
20S proteasome
Proteasome capacity
Online Access:http://link.springer.com/article/10.1186/s12868-018-0468-2

Internet

http://link.springer.com/article/10.1186/s12868-018-0468-2

Similar Items