Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population

Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population

Taxanes are a mainstay of treatment for breast cancer, but resistance often develops followed by metastatic disease and mortality. Aiming to reveal the mechanisms underlying taxane resistance, we used breast cancer patient-derived orthoxenografts (PDX). Mimicking clinical behavior, triple-negative b...

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Bibliographic Details
Main Authors: Jorge Gómez-Miragaya, Marta Palafox, Laia Paré, Guillermo Yoldi, Irene Ferrer, Sergi Vila, Patricia Galván, Pasquale Pellegrini, Hector Pérez-Montoyo, Ana Igea, Purificación Muñoz, Manel Esteller, Angel R. Nebreda, Ander Urruticoechea, Idoia Morilla, Sonia Pernas, Fina Climent, María Teresa Soler-Monso, Ana Petit, Violeta Serra, Aleix Prat, Eva González-Suárez
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Stem Cell Reports
Subjects:
TNBC
triple-negative breast cancer
PDX
patient-derived orthoxenografts
chemoresistance
docetaxel
CD49f tumor-initiating cells
drug holidays
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117301339

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http://www.sciencedirect.com/science/article/pii/S2213671117301339

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