PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. The resultant mutant Htt protein (mHtt) forms aggregates in the brain (e.g., cortex and striatum), and causes devastating neuronal degeneration. Tra...

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Bibliographic Details
Main Authors: Ming-Chang Chiang, Yijuang Chern, Rong-Nan Huang
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
Huntingtin
Thiazolidinedione
PPARγ
PGC-1α
Mitochondrial function
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002828

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http://www.sciencedirect.com/science/article/pii/S0969996111002828

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