YWHAG Mutations Cause Childhood Myoclonic Epilepsy and Febrile Seizures: Molecular Sub-regional Effect and Mechanism

YWHAG Mutations Cause Childhood Myoclonic Epilepsy and Febrile Seizures: Molecular Sub-regional Effect and Mechanism

YWHAG, which encodes an adapter protein 14-3-3γ, is highly expressed in the brain and regulates a diverse range of cell signaling pathways. Previously, eight YWHAG mutations have been identified in patients with epileptic encephalopathy (EE). In this study, using trios-based whole exome sequencing,...

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Bibliographic Details
Main Authors: Xing-Guang Ye, Zhi-Gang Liu, Jie Wang, Jie-Min Dai, Pei-Xiu Qiao, Ping-Ming Gao, Wei-Ping Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
YWHAG gene
14-3-3γ
myoclonic epilepsy
febrile seizures
molecular sub-regional effect
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.632466/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.632466/full

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