Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome

Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome

We have previously demonstrated that activation of serotonin 5-HT7 receptors (5-HT7R) reverses metabotropic glutamate receptor-mediated long term depression (mGluR-LTD) in the hippocampus of wild-type (WT) and Fmr1 Knockout (KO) mice, a model of Fragile X Syndrome (FXS) in which mGluR-LTD is abnorma...

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Bibliographic Details
Main Authors: Lara Costa, Lara Maria Sardone, Carmela Maria Bonaccorso, Simona D’Antoni, Michela Spatuzza, Walter Gulisano, Maria Rosaria Tropea, Daniela Puzzo, Marcello Leopoldo, Enza Lacivita, Maria Vincenza Catania, Lucia Ciranna
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
serotonin
5-HT7 receptor
fragile X syndrome
cyclic AMP
mGluR-LTD
learning
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00353/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00353/full

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