Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells

Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells

In vitro experiments have demonstrated that exogenous phospholipid transfer protein (PLTP), i.e. purified PLTP added to macrophage cultures, influences ABCA1-mediated cholesterol efflux from macrophages to HDL. To investigate whether PLTP produced by the macrophages (i.e., endogenous PLTP) is also p...

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Bibliographic Details
Main Authors: Miriam Lee-Rueckert, Riikka Vikstedt, Jari Metso, Christian Ehnholm, Petri T. Kovanen, Matti Jauhiainen
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Journal of Lipid Research
Subjects:
cholesterol loading
cholesterol efflux
ATP binding cassette transporter protein-1 upregulation
cyclic AMP
PLTP deficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520331576

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http://www.sciencedirect.com/science/article/pii/S0022227520331576

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