Long-Lasting Mucosal and Systemic Immunity against Influenza A Virus Is Significantly Prolonged and Protective by Nasal Whole Influenza Immunization with Mucosal Adjuvant N3 and DNA-Plasmid Expressing Flagellin in Aging In- and Outbred Mice

<i>Background</i>: Vaccination is commonly used to prevent and control influenza infection in humans. However, improvements in the ease of delivery and strength of immunogenicity could markedly improve herd immunity. The aim of this pre-clinical study is to test the potential improvement...

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Bibliographic Details
Main Authors: Jorma Hinkula, Sanna Nyström, Claudia Devito, Andreas Bråve, Steven E. Applequist
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/7/3/64