Thieno[2,3-<i>b</i>]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s<sup>+</sup> Breast Cancer Cells

Thieno[2,3-<i>b</i>]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s<sup>+</sup> Breast Cancer Cells

The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous metastasis and might be similar to the recruitment of leukocytes at the site of inflammation. It is mediated by E-selectin and its ligands, of which the most stereospecific is a glycoconjugate sialyl Lewis x (...

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Bibliographic Details
Main Authors: Sandra Marijan, Angela Mastelić, Anita Markotić, Nikolina Režić-Mužinić, Nikolina Vučenović, David Barker, Lisa I. Pilkington, Jóhannes Reynisson, Vedrana Čikeš Čulić
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Medicines
Subjects:
triple-negative breast cancer
thieno[2,3-<i>b</i>]pyridine
CD15s glycosphingolipid
CD15s glycoprotein
CD44
CD24
Online Access:https://www.mdpi.com/2305-6320/8/7/32

Internet

https://www.mdpi.com/2305-6320/8/7/32

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