1,2-Substituted 4-(1H)-Quinolones: Synthesis, Antimalarial and Antitrypanosomal Activities in Vitro

1,2-Substituted 4-(1H)-Quinolones: Synthesis, Antimalarial and Antitrypanosomal Activities in Vitro

A diverse array of 4-(1H)-quinolone derivatives bearing substituents at positions 1 and 2 were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense, and cytotoxicity against L-6 cells in vitro. Furthermore, selectivity indices were a...

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Bibliographic Details
Main Authors: Abraham Wube, Antje Hüfner, Werner Seebacher, Marcel Kaiser, Reto Brun, Rudolf Bauer, Franz Bucar
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Molecules
Subjects:
4-(1H)-quinolone
antimalarial
antitrypanosomal
cytotoxicity
SAR
Online Access:http://www.mdpi.com/1420-3049/19/9/14204

Internet

http://www.mdpi.com/1420-3049/19/9/14204

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