Analysis of metabolic network disruption in engineered microbial hosts due to enzyme promiscuity

Analysis of metabolic network disruption in engineered microbial hosts due to enzyme promiscuity

Increasing understanding of metabolic and regulatory networks underlying microbial physiology has enabled creation of progressively more complex synthetic biological systems for biochemical, biomedical, agricultural, and environmental applications. However, despite best efforts, confounding phenotyp...

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Bibliographic Details
Main Authors: Vladimir Porokhin, Sara A. Amin, Trevor B. Nicks, Venkatesh Endalur Gopinarayanan, Nikhil U. Nair, Soha Hassoun
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Metabolic Engineering Communications
Subjects:
Metabolic disruption
Enzyme promiscuity
Metabolic models
Metabolic engineering
Synthetic biology
Bio design automation
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030121000109

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http://www.sciencedirect.com/science/article/pii/S2214030121000109

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