A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics

A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics

How left-right patterning drives asymmetric morphogenesis is unclear. Here, we have quantified shape changes during mouse heart looping, from 3D reconstructions by HREM. In combination with cell labelling and computer simulations, we propose a novel model of heart looping. Buckling, when the cardiac...

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Bibliographic Details
Main Authors: Jean-François Le Garrec, Jorge N Domínguez, Audrey Desgrange, Kenzo D Ivanovitch, Etienne Raphaël, J Andrew Bangham, Miguel Torres, Enrico Coen, Timothy J Mohun, Sigolène M Meilhac
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
left-right patterning
heart morphogenesis
computer modelling
3D shape
Online Access:https://elifesciences.org/articles/28951

Internet

https://elifesciences.org/articles/28951

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