TFH Cells Induced by Vaccination and Following SIV Challenge Support Env-Specific Humoral Immunity in the Rectal-Genital Tract and Circulation of Female Rhesus Macaques

TFH Cells Induced by Vaccination and Following SIV Challenge Support Env-Specific Humoral Immunity in the Rectal-Genital Tract and Circulation of Female Rhesus Macaques

T follicular helper (TFH) cells are pivotal in lymph node (LN) germinal center (GC) B cell affinity maturation. Circulating CXCR5+ CD4+ T (cTFH) cells have supported memory B cell activation and broadly neutralizing antibodies in HIV controllers. We investigated the contribution of LN SIV-specific T...

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Bibliographic Details
Main Authors: Sabrina Helmold Hait, Christopher James Hogge, Mohammad Arif Rahman, Ruth Hunegnaw, Zuena Mushtaq, Tanya Hoang, Marjorie Robert-Guroff
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
TFH cells
B cell help
humoral immunity
rhesus macaque
SIV vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.608003/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.608003/full

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