Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients

Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients

Sodium glucose cotransporter 2 inhibitors (SGLT2i) are the first antidiabetic compounds that effectively reduce heart failure hospitalization and cardiovascular death in type 2 diabetics. Being explicitly designed to inhibit SGLT2 in the kidney, SGLT2i have lately been investigated for their off-tar...

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Bibliographic Details
Main Authors: Laween Uthman, Antonius Baartscheer, Cees A. Schumacher, Jan W. T. Fiolet, Marius C. Kuschma, Markus W. Hollmann, Ruben Coronel, Nina C. Weber, Coert J. Zuurbier
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Physiology
Subjects:
SGLT2 inhibitors
cardiomyocyte
endothelial cell
smooth muscle cell
cardiac fibroblast
isolated heart
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01575/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01575/full

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