Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.

Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway has been reported. Here we investigate such a link in mammals. We show that Sirt1 positively regulates insulin secret...

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Bibliographic Details
Main Authors: Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarente
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1318478?pdf=render

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http://europepmc.org/articles/PMC1318478?pdf=render

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